InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: IFT46

Summary

InnateDB Protein

IDBP-682899.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFT46

Protein Name

Intraflagellar transport protein 46 homolog

Synonyms

C11orf60; C15H11orf60;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000017195

InnateDB Gene

IDBG-631369 (IFT46)

Protein Structure

UniProt Annotation

Function

Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Cell projection, cilium {ECO:0000250}. Note=Expression is concentrated at the cilium basal body but is also detected along the length of the cilium. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007224	smoothened signaling pathway
GO:0042073	intraciliary transport
GO:0042384	cilium assembly

Cellular Component

GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005856	cytoskeleton
GO:0005929	cilium
GO:0030992	intraciliary transport particle B
GO:0031512	motile primary cilium
GO:0042995	cell projection
GO:0043234	protein complex
GO:0072372	primary cilium

Protein Structure and Domains

PDB ID

InterPro

IPR022088 Intraflagellar transport complex B protein 46

PFAM

PF12317

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q1LZB4

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

505579

UniGene

Bt.4015

RefSeq

NP_001068677

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC116107

GenPept

AAI16108