InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.25287

Summary

InnateDB Protein

IDBP-682960.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.25287

Protein Name

Tyrosine-protein kinase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000015986

InnateDB Gene

IDBG-631361 (BT.25287)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 99 interaction(s) predicted by orthology.

Predicted by orthology
Total	99 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005102	receptor binding
GO:0005143	interleukin-12 receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0020037	heme binding
GO:0035401	histone kinase activity (H3-Y41 specific)
GO:0042169	SH2 domain binding
GO:0042393	histone binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007167	enzyme linked receptor protein signaling pathway
GO:0007259	JAK-STAT cascade
GO:0007260	tyrosine phosphorylation of STAT protein
GO:0007262	STAT protein import into nucleus
GO:0008285	negative regulation of cell proliferation
GO:0010811	positive regulation of cell-substrate adhesion
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030099	myeloid cell differentiation
GO:0030154	cell differentiation
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0034050	host programmed cell death induced by symbiont
GO:0034612	response to tumor necrosis factor
GO:0035409	histone H3-Y41 phosphorylation
GO:0035556	intracellular signal transduction
GO:0035722	interleukin-12-mediated signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0043392	negative regulation of DNA binding
GO:0046677	response to antibiotic
GO:0050727	regulation of inflammatory response
GO:0060396	growth hormone receptor signaling pathway
GO:0061180	mammary gland epithelium development
GO:0070671	response to interleukin-12
GO:0097191	extrinsic apoptotic signaling pathway
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005901	caveola
GO:0016020	membrane
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

InterPro

IPR000299 FERM domain
IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR020693 Tyrosine-protein kinase, non-receptor Jak2

PFAM

PF00069
PF00017
PF14633
PF07714
PF00373

PRINTS

PR00401
PR00109
PR01823
PR01825

PIRSF

PIRSF000636

SMART

SM00252
SM00220
SM00295
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References