Version 5.4
Bos taurus Protein: UPK2
Summary
InnateDB Protein IDBP-683009.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UPK2
Protein Name Uroplakin-2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000016947
InnateDB Gene IDBG-631468 (UPK2)
Protein Structure
UniProt Annotation
Function Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM.
Subcellular Localization Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Heterodimer formation with UPK1A is a prerequisite to exit out of the endoplasmic reticulum (ER). {ECO:0000269PubMed:12475947}.
Disease Associations
Tissue Specificity Bladder epithelium.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0030855 epithelial cell differentiation
GO:0061024 membrane organization
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR009952 Uroplakin II
PFAM PF07353
PRINTS
PIRSF PIRSF016439
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q08537
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281569
UniGene Bt.110
RefSeq NP_776639
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL L20633
GenPept AAC37317

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca