Version 5.4
Bos taurus Protein: CBLN1
Summary
InnateDB Protein IDBP-683068.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CBLN1
Protein Name Cerebellin-1Cerebellin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000020212
InnateDB Gene IDBG-631528 (CBLN1)
Protein Structure
UniProt Annotation
Function Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity). {ECO:0000250}.The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0007157 heterophilic cell-cell adhesion
GO:0009306 protein secretion
GO:0021707 cerebellar granule cell differentiation
GO:0051965 positive regulation of synapse assembly
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030054 cell junction
GO:0045202 synapse
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR001073 Complement C1q protein
IPR008983 Tumour necrosis factor-like domain
PFAM PF00386
PRINTS PR00007
PIRSF
SMART SM00110
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P86437
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 618604
UniGene Bt.32914
RefSeq NP_001181981
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AAFC03072883
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca