InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CLN5

Summary

InnateDB Protein

IDBP-683507.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLN5

Protein Name

Ceroid-lipofuscinosis neuronal protein 5

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000025093

InnateDB Gene

IDBG-631935 (CLN5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Lysosome {ECO:0000250}.

Disease Associations

Note=Defects in CLN5 are the cause of neuronal ceroid lipofuscinosis (NCL). NCL is characterized by brain atrophy and the accumulation of lysosome derived fluorescent storage bodies in neurons and most other cells. NCL is found in Australian Devon cattle.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005537	mannose binding

Biological Process

GO:0006465	signal peptide processing
GO:0007040	lysosome organization
GO:0007042	lysosomal lumen acidification
GO:0007420	brain development
GO:0007601	visual perception
GO:0008219	cell death
GO:0022008	neurogenesis
GO:0070085	glycosylation

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005775	vacuolar lumen
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q1ZYR0

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

529186

UniGene

Bt.74270

RefSeq

NP_001039764

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DQ421787

GenPept

ABD83352