Version 5.4
Bos taurus Protein: PML
Summary
InnateDB Protein IDBP-683522.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PML
Protein Name promyelocytic leukemia
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000020952
InnateDB Gene IDBG-631902 (PML)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 160 interaction(s) predicted by orthology.
Predicted by orthology
Total 160 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0031625 ubiquitin protein ligase binding
GO:0032183 SUMO binding
GO:0042803 protein homodimerization activity
GO:0046332 SMAD binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0050897 cobalt ion binding
Biological Process
GO:0001666 response to hypoxia
GO:0001932 regulation of protein phosphorylation
GO:0002230 positive regulation of defense response to virus by host
GO:0006355 regulation of transcription, DNA-templated
GO:0006461 protein complex assembly
GO:0006605 protein targeting
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007050 cell cycle arrest
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007182 common-partner SMAD protein phosphorylation
GO:0007184 SMAD protein import into nucleus
GO:0007569 cell aging
GO:0008285 negative regulation of cell proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009411 response to UV
GO:0010332 response to gamma radiation
GO:0010522 regulation of calcium ion transport into cytosol
GO:0016525 negative regulation of angiogenesis
GO:0030099 myeloid cell differentiation
GO:0030308 negative regulation of cell growth
GO:0030578 PML body organization
GO:0031065 positive regulation of histone deacetylation
GO:0032211 negative regulation of telomere maintenance via telomerase
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0032922 circadian regulation of gene expression
GO:0032938 negative regulation of translation in response to oxidative stress
GO:0034097 response to cytokine
GO:0042752 regulation of circadian rhythm
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043153 entrainment of circadian clock by photoperiod
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087 innate immune response
GO:0045165 cell fate commitment
GO:0045343 regulation of MHC class I biosynthetic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045930 negative regulation of mitotic cell cycle
GO:0048384 retinoic acid receptor signaling pathway
GO:0050821 protein stabilization
GO:0051457 maintenance of protein location in nucleus
GO:0051974 negative regulation of telomerase activity
GO:0060058 positive regulation of apoptotic process involved in mammary gland involution
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071353 cellular response to interleukin-4
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0090398 cellular senescence
GO:0097191 extrinsic apoptotic signaling pathway
GO:1902187 negative regulation of viral release from host cell
GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000779 regulation of double-strand break repair
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016363 nuclear matrix
GO:0016605 PML body
GO:0031965 nuclear membrane
GO:0042406 extrinsic component of endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID
InterPro IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR021978 Protein of unknown function DUF3583
PFAM PF00643
PF13639
PF14634
PF12126
PRINTS
PIRSF
SMART SM00336
SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F6R1H3
UniProt Splice Variant
Entrez Gene 100138545
UniGene
RefSeq XP_005221963
HUGO HGNC:9113
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02052519 DAAA02052520
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca