InnateDB Protein
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IDBP-683530.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DPY30
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Protein Name
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Protein dpy-30 homolog
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000012183
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InnateDB Gene
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IDBG-631949 (DPY30)
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Protein Structure
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Function |
As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
25 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007858
Dpy-30 motif
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PFAM |
PF05186
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q2NKU6
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
513162
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UniGene |
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RefSeq |
NP_001071384
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC111634
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GenPept |
AAI11635
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