InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: HACE1

Summary

InnateDB Protein

IDBP-683549.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HACE1

Protein Name

HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000002010

InnateDB Gene

IDBG-631958 (HACE1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016874	ligase activity
GO:0017137	Rab GTPase binding
GO:0048365	Rac GTPase binding

Biological Process

GO:0007030	Golgi organization
GO:0016567	protein ubiquitination
GO:0030334	regulation of cell migration
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0061025	membrane fusion
GO:0070936	protein K48-linked ubiquitination

Cellular Component

GO:0000139

Golgi membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000569 HECT
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00632
PF00023
PF13606
PF11929
PF12796

PRINTS

PR01415

PIRSF

SMART

SM00119
SM00248

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

H9GW30

UniProt Splice Variant

Entrez Gene

527565

UniGene

Bt.30832

RefSeq

NP_001179574

HUGO

HGNC:21033

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02026050 DAAA02026051 DAAA02026052 DAAA02026053

GenPept