InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: NLRC4

Summary

InnateDB Protein

IDBP-683558.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NLRC4

Protein Name

NLR family, CARD domain containing 4

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000010814

InnateDB Gene

IDBG-631977 (NLRC4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0002218	activation of innate immune response
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954	inflammatory response
GO:0016045	detection of bacterium
GO:0042742	defense response to bacterium
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050702	interleukin-1 beta secretion
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051260	protein homooligomerization
GO:0070269	pyroptosis

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0072557	IPAF inflammasome complex

Protein Structure and Domains

PDB ID

InterPro

IPR001315 CARD domain
IPR007111 NACHT nucleoside triphosphatase
IPR011029 Death-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00619

PRINTS

PIRSF

SMART

SM00114

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite