InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: NUDT21

Summary

InnateDB Protein

IDBP-683631.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUDT21

Protein Name

Cleavage and polyadenylation specificity factor subunit 5

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000013467

InnateDB Gene

IDBG-632047 (NUDT21)

Protein Structure

UniProt Annotation

Function

Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.

Predicted by orthology
Total	77 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0017091	AU-rich element binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006378	mRNA polyadenylation
GO:0006397	mRNA processing
GO:0051262	protein tetramerization

Cellular Component

GO:0005634	nucleus
GO:0005813	centrosome
GO:0005849	mRNA cleavage factor complex
GO:0042382	paraspeckles

Protein Structure and Domains

PDB ID

InterPro

IPR015797 NUDIX hydrolase domain-like
IPR016706 Cleavage/polyadenylation specificity factor subunit 5

PFAM

PF13869

PRINTS

PIRSF

PIRSF017888

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3ZCA2

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

518859

UniGene

Bt.49427

RefSeq

NP_001030408

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102697

GenPept

AAI02698