Bos taurus Protein: FMO3 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Protein | IDBP-683689.2 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | FMO3 | ||||||||||||||
Protein Name | Dimethylaniline monooxygenase | ||||||||||||||
Synonyms | FM03; | ||||||||||||||
Species | Bos taurus | ||||||||||||||
Ensembl Protein | ENSBTAP00000027444 | ||||||||||||||
InnateDB Gene | IDBG-632092 (FMO3) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Acts on TMA to produce TMA-N-oxide. {ECO:0000269PubMed:12466292}. | ||||||||||||||
Subcellular Localization | Microsome membrane {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. | ||||||||||||||
Disease Associations | Note=Defects in FMO3 are the cause of a fishy off-flavor in cow milk due to by an elevated level of trimethylamine (TMA) in body fluids. {ECO:0000269PubMed:12466292}. | ||||||||||||||
Tissue Specificity | |||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||
PDB ID | |||||||||||||||
InterPro |
IPR000960
Flavin monooxygenase FMO IPR002253 Flavin monooxygenase (FMO) 1 IPR002254 Flavin monooxygenase (FMO) 2 IPR002255 Flavin monooxygenase (FMO) 3 IPR012143 Dimethylaniline monooxygenase, N-oxide-forming IPR020946 Flavin monooxygenase-like IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain |
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PFAM |
PF00743
PF07992 |
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PRINTS |
PR00370
PR01121 PR01122 PR01123 |
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PIRSF |
PIRSF000332
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SMART | |||||||||||||||
TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q8HYJ9 | ||||||||||||||
PhosphoSite | PhosphoSite- | ||||||||||||||
TrEMBL | Q8HYK4 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 281167 | ||||||||||||||
UniGene | Bt.12519 | ||||||||||||||
RefSeq | NP_776482 | ||||||||||||||
HUGO | |||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | AF488417 AF488418 AF488419 AF488420 AF488421 AF488422 | ||||||||||||||
GenPept | AAN27919 AAN27920 AAN27921 AAN27922 AAN27923 AAN27924 | ||||||||||||||