Version 5.4
Bos taurus Protein: ATP6V0A2
Summary
InnateDB Protein IDBP-683694.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP6V0A2
Protein Name V-type proton ATPase 116 kDa subunit a isoform 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000009563
InnateDB Gene IDBG-632091 (ATP6V0A2)
Protein Structure
UniProt Annotation
Function Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in lung, kidney and spleen.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015078 hydrogen ion transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0015991 ATP hydrolysis coupled proton transport
GO:0015992 proton transport
Cellular Component
GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain
GO:0001669 acrosomal vesicle
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0033179 proton-transporting V-type ATPase, V0 domain
Protein Structure and Domains
PDB ID
InterPro IPR002490 V-type ATPase, V0 complex, 116kDa subunit family
PFAM PF01496
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O97681
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 338038
UniGene Bt.16017
RefSeq NP_788810
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF105016
GenPept AAD12058

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca