Version 5.4
Bos taurus Protein: PIK3CG
Summary
InnateDB Protein IDBP-683720.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIK3CG
Protein Name phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000027780
InnateDB Gene IDBG-632081 (PIK3CG)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0046875 ephrin receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007186 G-protein coupled receptor signaling pathway
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0016310 phosphorylation
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0043406 positive regulation of MAP kinase activity
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:2000270 negative regulation of fibroblast apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0005944 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR002420 Phosphatidylinositol 3-kinase, C2 domain
IPR011009 Protein kinase-like domain
IPR016024 Armadillo-type fold
IPR029071 Ubiquitin-related domain
PFAM PF00168
PF00794
PF00454
PF00613
PF00792
PRINTS PR00360
PIRSF
SMART SM00239
SM00144
SM00146
SM00145
SM00142
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A6QPT0
UniProt Splice Variant
Entrez Gene 530001
UniGene Bt.46991
RefSeq NP_001095595
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC149468 DAAA02010571 DAAA02010572 DAAA02010573
GenPept AAI49469

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca