Version 5.4
Bos taurus Protein: BGN
Summary
InnateDB Protein IDBP-683872.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BGN
Protein Name Biglycan
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000044462
InnateDB Gene IDBG-632269 (BGN)
Protein Structure
UniProt Annotation
Function May be involved in collagen fiber assembly.
Subcellular Localization Secreted, extracellular space, extracellular matrix.
Disease Associations
Tissue Specificity Found in several connective tissues, especially in articular cartilages.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005539 glycosaminoglycan binding
GO:0050840 extracellular matrix binding
Biological Process
GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005622 intracellular
GO:0009986 cell surface
GO:0030133 transport vesicle
GO:0031012 extracellular matrix
GO:0042383 sarcolemma
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR016352 Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan
PFAM PF01462
PF00560
PF13504
PF13855
PRINTS
PIRSF PIRSF002490
SMART SM00013
SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P21809
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 280733
UniGene Bt.5351
RefSeq NP_847888
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118460 BT021201 S82652
GenPept AAB46746 AAI18461 AAX31383

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca