InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MFN2

Summary

InnateDB Protein

IDBP-684049.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MFN2

Protein Name

mitofusin 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000043671

InnateDB Gene

IDBG-632397 (MFN2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0001825	blastocyst formation
GO:0006184	GTP catabolic process
GO:0006626	protein targeting to mitochondrion
GO:0007006	mitochondrial membrane organization
GO:0008053	mitochondrial fusion
GO:0046580	negative regulation of Ras protein signal transduction
GO:0048593	camera-type eye morphogenesis
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0051646	mitochondrion localization

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0015630	microtubule cytoskeleton
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001401 Dynamin, GTPase domain
IPR006884 Fzo/mitofusin HR2 domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00350
PF04799

PRINTS

PIRSF

SMART

SM00053

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E1BKT8

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

HGNC:16877

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02042947 DAAA02042948

GenPept