Version 5.4
Bos taurus Protein: CIAPIN1
Summary
InnateDB Protein IDBP-684099.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CIAPIN1
Protein Name Anamorsin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000002418
InnateDB Gene IDBG-632480 (CIAPIN1)
Protein Structure
UniProt Annotation
Function Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein NDOR1. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells. {ECO:0000255HAMAP-Rule:MF_03115}.
Subcellular Localization Cytoplasm {ECO:0000255HAMAP-Rule:MF_03115}. Nucleus {ECO:0000255HAMAP-Rule:MF_03115}. Mitochondrion intermembrane space {ECO:0000255HAMAP-Rule:MF_03115}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0009055 electron carrier activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0006915 apoptotic process
GO:0016226 iron-sulfur cluster assembly
GO:0030097 hemopoiesis
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
Protein Structure and Domains
PDB ID
InterPro IPR007785 Anamorsin
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF05093
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5EAC7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 535119
UniGene
RefSeq NP_001015659
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120105 BT020642
GenPept AAI20106 AAX08659

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca