InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: AKIRIN2

Summary

InnateDB Protein

IDBP-684199.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKIRIN2

Protein Name

Akirin-2

Synonyms

Akirin-2; C9H6ORF166;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000004897

InnateDB Gene

IDBG-632578 (AKIRIN2)

Protein Structure

UniProt Annotation

Function

Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250UniProtKB:Q53H80}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0019899	enzyme binding

Biological Process

GO:0002376	immune system process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0009790	embryo development
GO:0032496	response to lipopolysaccharide
GO:0032755	positive regulation of interleukin-6 production
GO:0045087	innate immune response
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0017053	transcriptional repressor complex

Protein Structure and Domains

PDB ID

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A8YXY8

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

614292

UniGene

Bt.36693

RefSeq

NP_001103557

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC104619

GenPept

AAI04620