Version 5.4
Bos taurus Protein: IL17A
Summary
InnateDB Protein IDBP-684249.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL17A
Protein Name Interleukin-17A
Synonyms IL-17; IL17;
Species Bos taurus
Ensembl Protein ENSBTAP00000002786
InnateDB Gene IDBG-632619 (IL17A)
Protein Structure
UniProt Annotation
Function Induces stromal cells to produce proinflammatory and hematopoietic cytokines. {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
Biological Process
GO:0006954 inflammatory response
GO:0032747 positive regulation of interleukin-23 production
GO:0045672 positive regulation of osteoclast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0071347 cellular response to interleukin-1
GO:0072537 fibroblast activation
GO:1900017 positive regulation of cytokine production involved in inflammatory response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR010345 Interleukin-17 family
IPR020440 Interleukin-17, chordata
IPR029034 Cystine-knot cytokine
PFAM PF06083
PRINTS PR01932
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q687Y7
PhosphoSite PhosphoSite-
TrEMBL Q9TUP5
UniProt Splice Variant
Entrez Gene 282863
UniGene Bt.12772
RefSeq NP_001008412
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF166487 AF412040 AF416586 EU682381
GenPept AAD46376 AAL08013 AAQ03220 ACD81652

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca