InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SFRP4

Summary

InnateDB Protein

IDBP-684307.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SFRP4

Protein Name

secreted frizzled-related protein 4

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000020424

InnateDB Gene

IDBG-632677 (SFRP4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001944	vasculature development
GO:0002092	positive regulation of receptor internalization
GO:0007275	multicellular organismal development
GO:0007420	brain development
GO:0008285	negative regulation of cell proliferation
GO:0008406	gonad development
GO:0010628	positive regulation of gene expression
GO:0016055	Wnt signaling pathway
GO:0043065	positive regulation of apoptotic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045606	positive regulation of epidermal cell differentiation
GO:0046329	negative regulation of JNK cascade
GO:0046697	decidualization
GO:0055062	phosphate ion homeostasis
GO:0060056	mammary gland involution
GO:0060429	epithelium development
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:1902174	positive regulation of keratinocyte apoptotic process
GO:2000119	negative regulation of sodium-dependent phosphate transport

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009986	cell surface

Protein Structure and Domains

PDB ID

InterPro

IPR001134 Netrin domain
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR018933 Netrin module, non-TIMP type
IPR020067 Frizzled domain

PFAM

PF01759
PF01392

PRINTS

PIRSF

SMART

SM00643
SM00063

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite