InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: POGLUT1

Summary

InnateDB Protein

IDBP-684376.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POGLUT1

Protein Name

Protein O-glucosyltransferase 1

Synonyms

KTELC1; MDS010;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000011287

InnateDB Gene

IDBG-632739 (POGLUT1)

Protein Structure

UniProt Annotation

Function

Dual specificity glycosyltransferase. Catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to EGF repeats, such as those found in F7, F9 and NOTCH2, on the consensus sequence C-X-S-X-P-C. Positively regulates Notch signaling without affecting Notch ligand binding (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016740	transferase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0030158	protein xylosyltransferase activity
GO:0035251	UDP-glucosyltransferase activity
GO:0035252	UDP-xylosyltransferase activity
GO:0046527	glucosyltransferase activity

Biological Process

GO:0006486	protein glycosylation
GO:0006493	protein O-linked glycosylation
GO:0008593	regulation of Notch signaling pathway
GO:0072358	cardiovascular system development

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR006598 Lipopolysaccharide-modifying protein

PFAM

PF05686

PRINTS

PIRSF

SMART

SM00672

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5E9Q1

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

511862

UniGene

Bt.33308

RefSeq

NP_001014903

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BT020869

GenPept

AAX08886