Version 5.4
Bos taurus Protein: CCNT1
Summary
InnateDB Protein IDBP-684479.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCNT1
Protein Name Cyclin-T1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000007703
InnateDB Gene IDBG-632814 (CCNT1)
Protein Structure
UniProt Annotation
Function Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.
Predicted by orthology
Total 68 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0017069 snRNA binding
GO:0019901 protein kinase binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0016032 viral process
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0008024 positive transcription elongation factor complex b
Protein Structure and Domains
PDB ID
InterPro IPR006671 Cyclin, N-terminal
IPR013763 Cyclin-like
PFAM PF00134
PRINTS
PIRSF
SMART SM00385
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6T8E9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 407194
UniGene Bt.47956
RefSeq NP_001001147
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY428555
GenPept AAQ93805

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca