Version 5.4
Bos taurus Protein: S100A14
Summary
InnateDB Protein IDBP-684486.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol S100A14
Protein Name Protein S100-A14
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000028498
InnateDB Gene IDBG-632829 (S100A14)
Protein Structure
UniProt Annotation
Function Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0042379 chemokine receptor binding
Biological Process
GO:0006915 apoptotic process
GO:0032496 response to lipopolysaccharide
GO:0034142 toll-like receptor 4 signaling pathway
GO:0042742 defense response to bacterium
GO:0071624 positive regulation of granulocyte chemotaxis
GO:0090026 positive regulation of monocyte chemotaxis
Cellular Component
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR013787 S100/CaBP-9k-type, calcium binding, subdomain
PFAM PF01023
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3MHP3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 618250
UniGene Bt.76113
RefSeq NP_001073102
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105161
GenPept AAI05162

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca