Version 5.4
Bos taurus Protein: CAV1
Summary
InnateDB Protein IDBP-684491.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAV1
Protein Name Caveolin-1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000023751
InnateDB Gene IDBG-632834 (CAV1)
Protein Structure
UniProt Annotation
Function Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G- protein alpha subunits and can functionally regulate their activity. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane raft {ECO:0000250}. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 115 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 115 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0016504 peptidase activator activity
GO:0019899 enzyme binding
GO:0050998 nitric-oxide synthase binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000165 MAPK cascade
GO:0000188 inactivation of MAPK activity
GO:0001525 angiogenesis
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0002026 regulation of the force of heart contraction
GO:0002931 response to ischemia
GO:0003057 regulation of the force of heart contraction by chemical signal
GO:0006641 triglyceride metabolic process
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006940 regulation of smooth muscle contraction
GO:0007519 skeletal muscle tissue development
GO:0007595 lactation
GO:0008104 protein localization
GO:0008150 biological_process
GO:0008285 negative regulation of cell proliferation
GO:0009267 cellular response to starvation
GO:0009968 negative regulation of signal transduction
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0010952 positive regulation of peptidase activity
GO:0016050 vesicle organization
GO:0019217 regulation of fatty acid metabolic process
GO:0019915 lipid storage
GO:0030193 regulation of blood coagulation
GO:0030514 negative regulation of BMP signaling pathway
GO:0030857 negative regulation of epithelial cell differentiation
GO:0030879 mammary gland development
GO:0031295 T cell costimulation
GO:0031397 negative regulation of protein ubiquitination
GO:0032091 negative regulation of protein binding
GO:0032570 response to progesterone
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033484 nitric oxide homeostasis
GO:0042310 vasoconstriction
GO:0042524 negative regulation of tyrosine phosphorylation of Stat5 protein
GO:0042632 cholesterol homeostasis
GO:0043407 negative regulation of MAP kinase activity
GO:0043409 negative regulation of MAPK cascade
GO:0043627 response to estrogen
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045907 positive regulation of vasoconstriction
GO:0046426 negative regulation of JAK-STAT cascade
GO:0048550 negative regulation of pinocytosis
GO:0048554 positive regulation of metalloenzyme activity
GO:0051001 negative regulation of nitric-oxide synthase activity
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0051480 cytosolic calcium ion homeostasis
GO:0051592 response to calcium ion
GO:0051899 membrane depolarization
GO:0052547 regulation of peptidase activity
GO:0055074 calcium ion homeostasis
GO:0060056 mammary gland involution
GO:0070836 caveola assembly
GO:0071455 cellular response to hyperoxia
GO:0072584 caveolin-mediated endocytosis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097190 apoptotic signaling pathway
GO:2000286 receptor internalization involved in canonical Wnt receptor signaling pathway
GO:2000811 negative regulation of anoikis
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0002080 acrosomal membrane
GO:0005622 intracellular
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0005929 cilium
GO:0005938 cell cortex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0042383 sarcolemma
GO:0043234 protein complex
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001612 Caveolin
PFAM PF01146
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P79132
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281040
UniGene Bt.51574
RefSeq NP_776429
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY823915 DP000008 U86639
GenPept AAB47274 AAR16256 AAV83691

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca