InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MTOR

Summary

InnateDB Protein

IDBP-684577.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTOR

Protein Name

mechanistic target of rapamycin (serine/threonine kinase)

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000020386

InnateDB Gene

IDBG-632731 (MTOR)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 133 interaction(s) predicted by orthology.

Predicted by orthology
Total	133 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001030	RNA polymerase III type 1 promoter DNA binding
GO:0001031	RNA polymerase III type 2 promoter DNA binding
GO:0001032	RNA polymerase III type 3 promoter DNA binding
GO:0001156	TFIIIC-class transcription factor binding
GO:0004674	protein serine/threonine kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008144	drug binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0043022	ribosome binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0006950	response to stress
GO:0007281	germ cell development
GO:0010507	negative regulation of autophagy
GO:0010592	positive regulation of lamellipodium assembly
GO:0010628	positive regulation of gene expression
GO:0010831	positive regulation of myotube differentiation
GO:0016242	negative regulation of macroautophagy
GO:0016310	phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0030030	cell projection organization
GO:0030838	positive regulation of actin filament polymerization
GO:0031529	ruffle organization
GO:0031669	cellular response to nutrient levels
GO:0031929	TOR signaling
GO:0032314	regulation of Rac GTPase activity
GO:0032868	response to insulin
GO:0032956	regulation of actin cytoskeleton organization
GO:0043200	response to amino acid
GO:0045727	positive regulation of translation
GO:0045792	negative regulation of cell size
GO:0045859	regulation of protein kinase activity
GO:0045945	positive regulation of transcription from RNA polymerase III promoter
GO:0046777	protein autophosphorylation
GO:0046889	positive regulation of lipid biosynthetic process
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051496	positive regulation of stress fiber assembly
GO:0051534	negative regulation of NFAT protein import into nucleus
GO:0071456	cellular response to hypoxia

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005829	cytosol
GO:0012505	endomembrane system
GO:0016020	membrane
GO:0016605	PML body
GO:0031931	TORC1 complex
GO:0031932	TORC2 complex

Protein Structure and Domains

PDB ID

InterPro

IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR003151 PIK-related kinase, FAT
IPR003152 PIK-related kinase, FATC
IPR009076 Rapamycin-binding domain
IPR011009 Protein kinase-like domain
IPR014009 PIK-related kinase
IPR016024 Armadillo-type fold
IPR024585 Domain of unknown function DUF3385, target of rapamycin protein

PFAM

PF00454
PF02259
PF02260
PF08771
PF11865

PRINTS

PIRSF

SMART

SM00146

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite