InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: FKBP3

Summary

InnateDB Protein

IDBP-684668.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FKBP3

Protein Name

Peptidyl-prolyl cis-trans isomerase FKBP3

Synonyms

FKBP-3;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000003377

InnateDB Gene

IDBG-633002 (FKBP3)

Protein Structure

UniProt Annotation

Function

FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two dinstinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0005528	FK506 binding
GO:0016853	isomerase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0006457	protein folding
GO:0061077	chaperone-mediated protein folding

Cellular Component

GO:0005634	nucleus
GO:0005789	endoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
IPR013750 GHMP kinase, C-terminal domain

PFAM

PF00254
PF08544

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P26884

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

515069

UniGene

Bt.4478

RefSeq

NP_001033201

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC109932 M95123

GenPept

AAA30348 AAI09933