InnateDB Protein
|
IDBP-684783.2
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
PSMB4
|
Protein Name
|
Proteasome subunit beta type-4
|
Synonyms
|
|
Species
|
Bos taurus
|
Ensembl Protein
|
ENSBTAP00000028364
|
InnateDB Gene
|
IDBG-633103 (PSMB4)
|
Protein Structure
|
|
Function |
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Cytoplasm {ECO:0000255PROSITE- ProRule:PRU00809}. Nucleus {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
61 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0002862
|
negative regulation of inflammatory response to antigenic stimulus
|
GO:0006508
|
proteolysis
|
GO:0051603
|
proteolysis involved in cellular protein catabolic process
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001353
Proteasome, subunit alpha/beta
IPR016295
Proteasome endopeptidase complex, beta subunit
IPR029055
Nucleophile aminohydrolases, N-terminal
|
PFAM |
PF00227
|
PRINTS |
|
PIRSF |
PIRSF001213
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q3T108
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
506203
|
UniGene |
|
RefSeq |
NP_001029438
|
HUGO |
|
OMIM |
|
CCDS |
|
HPRD |
|
IMGT |
|
EMBL |
BC102182
|
GenPept |
AAI02183
|
|
|