Version 5.4
Bos taurus Protein: SLC38A2
Summary
InnateDB Protein IDBP-684850.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC38A2
Protein Name Sodium-coupled neutral amino acid transporter 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000014749
InnateDB Gene IDBG-633161 (SLC38A2)
Protein Structure
UniProt Annotation
Function Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes. May localize to an endosomal compartment. Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015171 amino acid transmembrane transporter activity
GO:0015293 symporter activity
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0006810 transport
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0006865 amino acid transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR013057 Amino acid transporter, transmembrane
PFAM PF01490
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2VE31
PhosphoSite PhosphoSite-
TrEMBL B2CZY3
UniProt Splice Variant
Entrez Gene 338044
UniGene Bt.9238
RefSeq NP_001075893
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AJ344100 BC133547 EU563219
GenPept AAI33548 ACB69717 CAC51429

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca