Version 5.4
Bos taurus Protein: NAE1
Summary
InnateDB Protein IDBP-684883.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAE1
Protein Name NEDD8 activating enzyme E1 subunit 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000013367
InnateDB Gene IDBG-633182 (NAE1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0019781 NEDD8 activating enzyme activity
GO:0031625 ubiquitin protein ligase binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0033314 mitotic DNA replication checkpoint
GO:0042981 regulation of apoptotic process
GO:0043523 regulation of neuron apoptotic process
GO:0045116 protein neddylation
GO:0051402 neuron apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000594 UBA/THIF-type NAD/FAD binding fold
IPR009036 Molybdenum cofactor biosynthesis, MoeB
PFAM PF00899
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E1B8X4
UniProt Splice Variant
Entrez Gene 614491
UniGene
RefSeq NP_001179962
HUGO HGNC:621
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02046678
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca