InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: FAM162A

Summary

InnateDB Protein

IDBP-684983.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FAM162A

Protein Name

Protein FAM162A

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000014796

InnateDB Gene

IDBG-633286 (FAM162A)

Protein Structure

UniProt Annotation

Function

Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006927	transformed cell apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0051402	neuron apoptotic process
GO:0071456	cellular response to hypoxia
GO:0090200	positive regulation of release of cytochrome c from mitochondria

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome