InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TWF1

Summary

InnateDB Protein

IDBP-685001.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TWF1

Protein Name

Twinfilin-1

Synonyms

PTK9;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000027889

InnateDB Gene

IDBG-633304 (TWF1)

Protein Structure

UniProt Annotation

Function

Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0003785	actin monomer binding
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding

Biological Process

GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030837	negative regulation of actin filament polymerization
GO:0042989	sequestering of actin monomers
GO:0043538	regulation of actin phosphorylation
GO:0051016	barbed-end actin filament capping

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005911	cell-cell junction
GO:0015629	actin cytoskeleton
GO:0030016	myofibril
GO:0030175	filopodium
GO:0032587	ruffle membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR002108 Actin-depolymerising factor homology domain

PFAM

PF00241

PRINTS

PIRSF

SMART

SM00102

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q56JV6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

506683

UniGene

Bt.5944

RefSeq

NP_001020491

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AY911376

GenPept

AAW82139