InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.50439

Summary

InnateDB Protein

IDBP-685003.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.50439

Protein Name

protein kinase C epsilon type

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000027471

InnateDB Gene

IDBG-633307 (BT.50439)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.

Predicted by orthology
Total	57 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003785	actin monomer binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004697	protein kinase C activity
GO:0004699	calcium-independent protein kinase C activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008047	enzyme activator activity
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019899	enzyme binding
GO:0030546	receptor activator activity
GO:0035276	ethanol binding
GO:0046872	metal ion binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0002281	macrophage activation involved in immune response
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0007155	cell adhesion
GO:0010634	positive regulation of epithelial cell migration
GO:0010763	positive regulation of fibroblast migration
GO:0010811	positive regulation of cell-substrate adhesion
GO:0016310	phosphorylation
GO:0019216	regulation of lipid metabolic process
GO:0030838	positive regulation of actin filament polymerization
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032024	positive regulation of insulin secretion
GO:0032230	positive regulation of synaptic transmission, GABAergic
GO:0032467	positive regulation of cytokinesis
GO:0035556	intracellular signal transduction
GO:0035641	locomotory exploration behavior
GO:0035669	TRAM-dependent toll-like receptor 4 signaling pathway
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043278	response to morphine
GO:0043410	positive regulation of MAPK cascade
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:0050996	positive regulation of lipid catabolic process
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051301	cell division
GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070257	positive regulation of mucus secretion
GO:0071361	cellular response to ethanol
GO:0071456	cellular response to hypoxia
GO:0090303	positive regulation of wound healing
GO:2000273	positive regulation of receptor activity
GO:2001031	positive regulation of cellular glucuronidation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0048471	perinuclear region of cytoplasm
GO:0071944	cell periphery

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR014376 Protein kinase C, delta/epsilon/eta/theta types
IPR017892 Protein kinase, C-terminal
IPR020454 Diacylglycerol/phorbol-ester binding
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00168
PF00069
PF07714
PF00130
PF00433

PRINTS

PR00360
PR00109
PR00008

PIRSF

PIRSF000551

SMART

SM00239
SM00133
SM00109
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References