Version 5.4
Bos taurus Protein: NEUROD6
Summary
InnateDB Protein IDBP-685070.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEUROD6
Protein Name Neurogenic differentiation factor 6
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000000728
InnateDB Gene IDBG-633371 (NEUROD6)
Protein Structure
UniProt Annotation
Function Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0007399 nervous system development
GO:0021542 dentate gyrus development
GO:0030154 cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR016637 Transcription factor, basic helix-loop-helix, NeuroD
IPR022575 Neurogenic differentiation factor, domain of unknown function
PFAM PF00010
PF12533
PRINTS
PIRSF PIRSF015618
SMART SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q08DI0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 540464
UniGene Bt.11684
RefSeq NP_001069689
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123740
GenPept AAI23741

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca