InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.105316

Summary

InnateDB Protein

IDBP-685139.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.105316

Protein Name

myosin light chain kinase, smooth muscle

Synonyms

MLCK; smMLCK;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000019385

InnateDB Gene

IDBG-633411 (BT.105316)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004687	myosin light chain kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006939	smooth muscle contraction
GO:0007015	actin filament organization
GO:0030335	positive regulation of cell migration
GO:0032060	bleb assembly
GO:0051928	positive regulation of calcium ion transport
GO:0060414	aorta smooth muscle tissue morphogenesis
GO:0071476	cellular hypotonic response
GO:0090303	positive regulation of wound healing

Cellular Component

GO:0001725	stress fiber
GO:0005737	cytoplasm
GO:0005911	cell-cell junction
GO:0030027	lamellipodium
GO:0032154	cleavage furrow
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM