InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: LRRK2

Summary

InnateDB Protein

IDBP-685197.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LRRK2

Protein Name

leucine-rich repeat kinase 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000053353

InnateDB Gene

IDBG-633456 (LRRK2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 135 interaction(s) predicted by orthology.

Predicted by orthology
Total	135 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0000166	nucleotide binding
GO:0001948	glycoprotein binding
GO:0003779	actin binding
GO:0003924	GTPase activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004708	MAP kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004857	enzyme inhibitor activity
GO:0005096	GTPase activator activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0015631	tubulin binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017048	Rho GTPase binding
GO:0017075	syntaxin-1 binding
GO:0030276	clathrin binding
GO:0034211	GTP-dependent protein kinase activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0044325	ion channel binding
GO:0051018	protein kinase A binding

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0000187	activation of MAPK activity
GO:0001933	negative regulation of protein phosphorylation
GO:0001934	positive regulation of protein phosphorylation
GO:0006184	GTP catabolic process
GO:0006468	protein phosphorylation
GO:0006979	response to oxidative stress
GO:0007264	small GTPase mediated signal transduction
GO:0007528	neuromuscular junction development
GO:0008340	determination of adult lifespan
GO:0010508	positive regulation of autophagy
GO:0010738	regulation of protein kinase A signaling
GO:0014041	regulation of neuron maturation
GO:0015031	protein transport
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0021772	olfactory bulb development
GO:0022028	tangential migration from the subventricular zone to the olfactory bulb
GO:0031398	positive regulation of protein ubiquitination
GO:0032091	negative regulation of protein binding
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034260	negative regulation of GTPase activity
GO:0034613	cellular protein localization
GO:0035556	intracellular signal transduction
GO:0035564	regulation of kidney size
GO:0035640	exploration behavior
GO:0035641	locomotory exploration behavior
GO:0040012	regulation of locomotion
GO:0042391	regulation of membrane potential
GO:0043068	positive regulation of programmed cell death
GO:0046777	protein autophosphorylation
GO:0048312	intracellular distribution of mitochondria
GO:0048812	neuron projection morphogenesis
GO:0051900	regulation of mitochondrial depolarization
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060159	regulation of dopamine receptor signaling pathway
GO:0060161	positive regulation of dopamine receptor signaling pathway
GO:0061001	regulation of dendritic spine morphogenesis
GO:0070997	neuron death
GO:1901214	regulation of neuron death
GO:1902692	regulation of neuroblast proliferation
GO:1902803	regulation of synaptic vesicle transport
GO:1903125	negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
GO:2000172	regulation of branching morphogenesis of a nerve
GO:2000300	regulation of synaptic vesicle exocytosis

Cellular Component

GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005802	trans-Golgi network
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0016234	inclusion body
GO:0030425	dendrite
GO:0031966	mitochondrial membrane
GO:0032473	external side of mitochondrial outer membrane
GO:0032839	dendrite cytoplasm
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0045121	membrane raft
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001611 Leucine-rich repeat
IPR001806 Small GTPase superfamily
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003579 Small GTPase superfamily, Rab type
IPR003591 Leucine-rich repeat, typical subtype
IPR005225 Small GTP-binding protein domain
IPR011009 Protein kinase-like domain
IPR013684 Mitochondrial Rho-like
IPR016024 Armadillo-type fold
IPR017986 WD40-repeat-containing domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM