Version 5.4
Bos taurus Protein: HOXA5
Summary
InnateDB Protein IDBP-685304.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOXA5
Protein Name Homeobox protein Hox-A5
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000016196
InnateDB Gene IDBG-633592 (HOXA5)
Protein Structure
UniProt Annotation
Function Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001501 skeletal system development
GO:0002009 morphogenesis of an epithelium
GO:0003016 respiratory system process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0007389 pattern specification process
GO:0007585 respiratory gaseous exchange
GO:0009952 anterior/posterior pattern specification
GO:0010870 positive regulation of receptor biosynthetic process
GO:0016477 cell migration
GO:0016525 negative regulation of angiogenesis
GO:0030324 lung development
GO:0030878 thyroid gland development
GO:0033599 regulation of mammary gland epithelial cell proliferation
GO:0035264 multicellular organism growth
GO:0043065 positive regulation of apoptotic process
GO:0045639 positive regulation of myeloid cell differentiation
GO:0045647 negative regulation of erythrocyte differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048286 lung alveolus development
GO:0048704 embryonic skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0060435 bronchiole development
GO:0060439 trachea morphogenesis
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060480 lung goblet cell differentiation
GO:0060481 lobar bronchus epithelium development
GO:0060484 lung-associated mesenchyme development
GO:0060535 trachea cartilage morphogenesis
GO:0060536 cartilage morphogenesis
GO:0060574 intestinal epithelial cell maturation
GO:0060638 mesenchymal-epithelial cell signaling
GO:0060644 mammary gland epithelial cell differentiation
GO:0060749 mammary gland alveolus development
GO:0060764 cell-cell signaling involved in mammary gland development
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR017995 Homeobox protein, antennapedia type
IPR020479 Homeodomain, metazoa
PFAM PF00046
PRINTS PR00025
PR00024
PIRSF
SMART SM00389
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2HJ67
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 768039
UniGene Bt.11342
RefSeq NP_001070566
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC113284
GenPept AAI13285

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca