Version 5.4
Bos taurus Protein: MELK
Summary
InnateDB Protein IDBP-685413.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MELK
Protein Name maternal embryonic leucine zipper kinase
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000028900
InnateDB Gene IDBG-633675 (MELK)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0008283 cell proliferation
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009103 lipopolysaccharide biosynthetic process
GO:0016310 phosphorylation
GO:0043065 positive regulation of apoptotic process
GO:0046777 protein autophosphorylation
GO:0061351 neural precursor cell proliferation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001772 Kinase associated domain 1 (KA1)
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR028375 KA1 domain/Ssp2 C-terminal domain
PFAM PF00069
PF07714
PF02149
PF06293
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A9Q1J5
UniProt Splice Variant
Entrez Gene 520088
UniGene Bt.25834
RefSeq NP_001104730
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02023147 DAAA02023148 EF446902
GenPept ABR15006

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca