Version 5.4
Bos taurus Protein: IRS2
Summary
InnateDB Protein IDBP-685421.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRS2
Protein Name insulin receptor substrate 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000049448
InnateDB Gene IDBG-633698 (IRS2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005158 insulin receptor binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0043548 phosphatidylinositol 3-kinase binding
Biological Process
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002903 negative regulation of B cell apoptotic process
GO:0007420 brain development
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0009749 response to glucose
GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport
GO:0010907 positive regulation of glucose metabolic process
GO:0030335 positive regulation of cell migration
GO:0030879 mammary gland development
GO:0030890 positive regulation of B cell proliferation
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0032024 positive regulation of insulin secretion
GO:0032869 cellular response to insulin stimulus
GO:0033673 negative regulation of kinase activity
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0046326 positive regulation of glucose import
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001849 Pleckstrin homology domain
IPR002404 Insulin receptor substrate-1, PTB
PFAM PF00169
PF02174
PRINTS PR00628
PIRSF
SMART SM00233
SM00310
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MJE0
UniProt Splice Variant
Entrez Gene 100300012
UniGene
RefSeq XP_005228650
HUGO HGNC:6126
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02034899 DAAA02034900 DAAA02034901
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca