Version 5.4
Bos taurus Protein: LGMN
Summary
InnateDB Protein IDBP-685483.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LGMN
Protein Name legumain precursor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000053922
InnateDB Gene IDBG-633756 (LGMN)
Protein Structure
UniProt Annotation
Function Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). Required for normal lysosomal protein degradation in renal proximal tubules. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. {ECO:0000250, ECO:0000269PubMed:11983426}.
Subcellular Localization Lysosome {ECO:0000269PubMed:11983426}.
Disease Associations
Tissue Specificity Detected in kidney (at protein level). {ECO:0000269PubMed:11983426}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0003014 renal system process
GO:0006508 proteolysis
GO:0010447 response to acidity
GO:0032801 receptor catabolic process
GO:0040015 negative regulation of multicellular organism growth
GO:0043524 negative regulation of neuron apoptotic process
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:1901185 negative regulation of ERBB signaling pathway
Cellular Component
GO:0005764 lysosome
GO:0005770 late endosome
GO:0045177 apical part of cell
Protein Structure and Domains
PDB ID
InterPro IPR001096 Peptidase C13, legumain
PFAM PF01650
PRINTS PR00776
PIRSF PIRSF019663
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q95M12
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281281
UniGene Bt.8947
RefSeq NP_776526
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB060129 BC111117
GenPept AAI11118 BAB69947

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca