Version 5.4
Bos taurus Protein: MIS12
Summary
InnateDB Protein IDBP-685708.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MIS12
Protein Name Protein MIS12 homolog
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000027230
InnateDB Gene IDBG-633967 (MIS12)
Protein Structure
UniProt Annotation
Function Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Associated with the kinetochore. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007049 cell cycle
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0051301 cell division
GO:0051382 kinetochore assembly
Cellular Component
GO:0000444 MIS12/MIND type complex
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005694 chromosome
Protein Structure and Domains
PDB ID
InterPro IPR008685 Centromere protein Mis12
PFAM PF05859
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5EA49
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 767858
UniGene Bt.24858
RefSeq NP_001070437
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC119961 BT020720
GenPept AAI19962 AAX08737

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca