InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PAK2

Summary

InnateDB Protein

IDBP-685821.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAK2

Protein Name

p21 protein (Cdc42/Rac)-activated kinase 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000054939

InnateDB Gene

IDBG-634020 (PAK2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.

Predicted by orthology
Total	77 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0030296	protein tyrosine kinase activator activity
GO:0042802	identical protein binding

Biological Process

GO:0006468	protein phosphorylation
GO:0016310	phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0023014	signal transduction by phosphorylation
GO:0043066	negative regulation of apoptotic process
GO:0046777	protein autophosphorylation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway
GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000095 CRIB domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00786
PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00285
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt