InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RPS27A

Summary

InnateDB Protein

IDBP-685887.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS27A

Protein Name

Ubiquitin-40S ribosomal protein S27aUbiquitin40S ribosomal protein S27a

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000033015

InnateDB Gene

IDBG-634133 (RPS27A)

Protein Structure

UniProt Annotation

Function

Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity). {ECO:0000250}.40S Ribosomal protein S27a: Component of the 40S subunit of the ribosome.

Subcellular Localization

Ubiquitin: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 174 interaction(s) predicted by orthology.

Predicted by orthology
Total	174 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006412

translation

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005840	ribosome
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022627	cytosolic small ribosomal subunit
GO:0030529	ribonucleoprotein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000626 Ubiquitin-like
IPR002906 Ribosomal protein S27a
IPR019956 Ubiquitin
IPR022617 Rad60/SUMO-like domain
IPR029071 Ubiquitin-related domain

PFAM

PF00240
PF14560
PF01599
PF11976

PRINTS

PR00348

PIRSF

SMART

SM00213

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P62992

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

286839

UniGene

Bt.13067

RefSeq

NP_777203

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AB098891 AF058700 BC102491

GenPept

AAC77907 AAI02492 BAC56381