Version 5.4
Bos taurus Protein: ERP44
Summary
InnateDB Protein IDBP-685962.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERP44
Protein Name Endoplasmic reticulum resident protein 44
Synonyms TXNDC4;
Species Bos taurus
Ensembl Protein ENSBTAP00000012930
InnateDB Gene IDBG-634194 (ERP44)
Protein Structure
UniProt Annotation
Function Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum lumen {ECO:0000255PROSITE-ProRule:PRU10138}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003756 protein disulfide isomerase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0006457 protein folding
GO:0006986 response to unfolded protein
GO:0009100 glycoprotein metabolic process
GO:0034976 response to endoplasmic reticulum stress
GO:0045454 cell redox homeostasis
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0009986 cell surface
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001393 Calsequestrin
IPR012336 Thioredoxin-like fold
IPR013766 Thioredoxin domain
PFAM PF01216
PF13098
PF13192
PF13462
PF13905
PF00085
PRINTS PR00312
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3T0L2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 506157
UniGene Bt.89221
RefSeq NP_001030204
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102349
GenPept AAI02350

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca