Version 5.4
Bos taurus Protein: HPX
Summary
InnateDB Protein IDBP-685967.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HPX
Protein Name Hemopexin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000004635
InnateDB Gene IDBG-634199 (HPX)
Protein Structure
UniProt Annotation
Function Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0002639 positive regulation of immunoglobulin production
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006810 transport
GO:0020027 hemoglobin metabolic process
GO:0042168 heme metabolic process
GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0051246 regulation of protein metabolic process
GO:0060332 positive regulation of response to interferon-gamma
GO:0060335 positive regulation of interferon-gamma-mediated signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID
InterPro IPR000585 Hemopexin-like domain
IPR016358 Hemopexin, chordata
IPR018487 Hemopexin-like repeats
PFAM PF00045
PRINTS
PIRSF PIRSF002551
SMART SM00120
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3SZV7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 534509
UniGene Bt.49204
RefSeq NP_001029784
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102687
GenPept AAI02688

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca