Version 5.4
Bos taurus Protein: CCKBR
Summary
InnateDB Protein IDBP-685979.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCKBR
Protein Name gastrin/cholecystokinin type B receptor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000006892
InnateDB Gene IDBG-634214 (CCKBR)
Protein Structure
UniProt Annotation
Function Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0015054 gastrin receptor activity
GO:0031741 type B gastrin/cholecystokinin receptor binding
Biological Process
GO:0001696 gastric acid secretion
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008284 positive regulation of cell proliferation
GO:0048565 digestive tract development
GO:0048732 gland development
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000314 Gastrin receptor
IPR000611 Neuropeptide Y receptor family
IPR009126 Cholecystokinin receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
PFAM PF00001
PF10320
PRINTS PR00237
PR00527
PR01012
PR01822
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P79266
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281665
UniGene Bt.86657
RefSeq NP_776687
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC112800 S83090
GenPept AAB46896 AAI12801

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca