InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DYRK2

Summary

InnateDB Protein

IDBP-686012.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DYRK2

Protein Name

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000009545

InnateDB Gene

IDBG-634243 (DYRK2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030145	manganese ion binding
GO:0043130	ubiquitin binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0007224	smoothened signaling pathway
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0051534	negative regulation of NFAT protein import into nucleus

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030529	ribonucleoprotein complex

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt