Version 5.4
Bos taurus Protein: HES1
Summary
InnateDB Protein IDBP-686093.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HES1
Protein Name Transcription factor HES-1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000056047
InnateDB Gene IDBG-634294 (HES1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0046983 protein dimerization activity
GO:0071820 N-box binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0001889 liver development
GO:0003143 embryonic heart tube morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003266 regulation of secondary heart field cardioblast proliferation
GO:0003281 ventricular septum development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006461 protein complex assembly
GO:0007155 cell adhesion
GO:0007219 Notch signaling pathway
GO:0007224 smoothened signaling pathway
GO:0007262 STAT protein import into nucleus
GO:0007389 pattern specification process
GO:0008284 positive regulation of cell proliferation
GO:0016477 cell migration
GO:0021537 telencephalon development
GO:0021555 midbrain-hindbrain boundary morphogenesis
GO:0021557 oculomotor nerve development
GO:0021558 trochlear nerve development
GO:0021575 hindbrain morphogenesis
GO:0021915 neural tube development
GO:0021983 pituitary gland development
GO:0021984 adenohypophysis development
GO:0030324 lung development
GO:0030513 positive regulation of BMP signaling pathway
GO:0030901 midbrain development
GO:0031016 pancreas development
GO:0035019 somatic stem cell maintenance
GO:0035909 aorta morphogenesis
GO:0035910 ascending aorta morphogenesis
GO:0042102 positive regulation of T cell proliferation
GO:0042491 auditory receptor cell differentiation
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042668 auditory receptor cell fate determination
GO:0043388 positive regulation of DNA binding
GO:0045165 cell fate commitment
GO:0045596 negative regulation of cell differentiation
GO:0045598 regulation of fat cell differentiation
GO:0045608 negative regulation of auditory receptor cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045977 positive regulation of mitotic cell cycle, embryonic
GO:0046331 lateral inhibition
GO:0046427 positive regulation of JAK-STAT cascade
GO:0048469 cell maturation
GO:0048505 regulation of timing of cell differentiation
GO:0048538 thymus development
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048711 positive regulation of astrocyte differentiation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0048844 artery morphogenesis
GO:0050767 regulation of neurogenesis
GO:0060164 regulation of timing of neuron differentiation
GO:0060253 negative regulation of glial cell proliferation
GO:0060412 ventricular septum morphogenesis
GO:0060675 ureteric bud morphogenesis
GO:0060716 labyrinthine layer blood vessel development
GO:0061009 common bile duct development
GO:0061106 negative regulation of stomach neuroendocrine cell differentiation
GO:0061309 cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0061626 pharyngeal arch artery morphogenesis
GO:0072012 glomerulus vasculature development
GO:0072049 comma-shaped body morphogenesis
GO:0072050 S-shaped body morphogenesis
GO:0072141 renal interstitial cell development
GO:0072282 metanephric nephron tubule morphogenesis
GO:0090102 cochlea development
GO:0097084 vascular smooth muscle cell development
GO:0097150 neuronal stem cell maintenance
GO:2000227 negative regulation of pancreatic A cell differentiation
GO:2000737 negative regulation of stem cell differentiation
GO:2000974 negative regulation of pro-B cell differentiation
GO:2000981 negative regulation of inner ear receptor cell differentiation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR003650 Orange
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR018352 Orange subgroup
PFAM PF07527
PF00010
PRINTS
PIRSF
SMART SM00353
SM00511
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G3N2D5
UniProt Splice Variant
Entrez Gene 539547
UniGene Bt.49417
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02001738
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca