Version 5.4
Bos taurus Protein: HMGA2
Summary
InnateDB Protein IDBP-686094.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMGA2
Protein Name high mobility group AT-hook 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000053383
InnateDB Gene IDBG-634324 (HMGA2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000975 regulatory region DNA binding
GO:0001047 core promoter binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003680 AT DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004677 DNA-dependent protein kinase activity
GO:0005515 protein binding
GO:0008301 DNA binding, bending
GO:0031492 nucleosomal DNA binding
GO:0035497 cAMP response element binding
GO:0035500 MH2 domain binding
GO:0035501 MH1 domain binding
GO:0051575 5'-deoxyribose-5-phosphate lyase activity
GO:0070742 C2H2 zinc finger domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000737 DNA catabolic process, endonucleolytic
GO:0001837 epithelial to mesenchymal transition
GO:0002062 chondrocyte differentiation
GO:0003131 mesodermal-endodermal cell signaling
GO:0006284 base-excision repair
GO:0006355 regulation of transcription, DNA-templated
GO:0007095 mitotic G2 DNA damage checkpoint
GO:0007283 spermatogenesis
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008584 male gonad development
GO:0010564 regulation of cell cycle process
GO:0010628 positive regulation of gene expression
GO:0021846 cell proliferation in forebrain
GO:0021983 pituitary gland development
GO:0030325 adrenal gland development
GO:0031052 chromosome breakage
GO:0031507 heterochromatin assembly
GO:0035019 somatic stem cell maintenance
GO:0035978 histone H2A-S139 phosphorylation
GO:0035986 senescence-associated heterochromatin focus assembly
GO:0035987 endodermal cell differentiation
GO:0035988 chondrocyte proliferation
GO:0040018 positive regulation of multicellular organism growth
GO:0042769 DNA damage response, detection of DNA damage
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0043922 negative regulation by host of viral transcription
GO:0045444 fat cell differentiation
GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048333 mesodermal cell differentiation
GO:0048712 negative regulation of astrocyte differentiation
GO:0048762 mesenchymal cell differentiation
GO:0060123 regulation of growth hormone secretion
GO:0060612 adipose tissue development
GO:0060613 fat pad development
GO:0071158 positive regulation of cell cycle arrest
GO:0090276 regulation of peptide hormone secretion
GO:0090402 oncogene-induced cell senescence
GO:2000036 regulation of stem cell maintenance
GO:2000648 positive regulation of stem cell proliferation
GO:2000679 positive regulation of transcription regulatory region DNA binding
GO:2000685 positive regulation of cellular response to X-ray
GO:2000774 positive regulation of cellular senescence
GO:2001022 positive regulation of response to DNA damage stimulus
GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining
GO:2001038 regulation of cellular response to drug
Cellular Component
GO:0000228 nuclear chromosome
GO:0000785 chromatin
GO:0005634 nucleus
GO:0032993 protein-DNA complex
GO:0035985 senescence-associated heterochromatin focus
GO:0071141 SMAD protein complex
Protein Structure and Domains
PDB ID
InterPro IPR000116 High mobility group, HMG-I/HMG-Y
IPR017956 AT hook, DNA-binding motif
IPR020478 AT hook-like
PFAM PF02178
PRINTS PR00930
PR00929
PIRSF
SMART SM00384
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E1BPQ4
UniProt Splice Variant
Entrez Gene 100297155
UniGene
RefSeq XP_002687694
HUGO HGNC:5009
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02013319
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca