InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PROZ

Summary

InnateDB Protein

IDBP-686105.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PROZ

Protein Name

Vitamin K-dependent protein Z

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000025894

InnateDB Gene

IDBG-634329 (PROZ)

Protein Structure

UniProt Annotation

Function

Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids (By similarity). Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0007599	hemostasis

Cellular Component

GO:0005576	extracellular region
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
IPR000742 Epidermal growth factor-like domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR001881 EGF-like calcium-binding domain
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z

PFAM

PF00594
PF00008
PF00089
PF07645

PRINTS

PR00001
PR00722

PIRSF

PIRSF001143

SMART

SM00069
SM00181
SM00020
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References