Version 5.4
Bos taurus Protein: LAMP1
Summary
InnateDB Protein IDBP-686194.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LAMP1
Protein Name Lysosome-associated membrane glycoprotein 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000042536
InnateDB Gene IDBG-634412 (LAMP1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000255PROSITE-ProRule:PRU00740}. Endosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000255PROSITE-ProRule:PRU00740}. Lysosome membrane {ECO:0000255PROSITE-ProRule:PRU00740}; Single-pass type I membrane protein {ECO:0000255PROSITE-ProRule:PRU00740}. Late endosome {ECO:0000250}. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
Biological Process
GO:0008626 granzyme-mediated apoptotic signaling pathway
GO:0043323 positive regulation of natural killer cell degranulation
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0050821 protein stabilization
GO:0072594 establishment of protein localization to organelle
GO:0090160 Golgi to lysosome transport
GO:1902513 regulation of organelle transport along microtubule
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005770 late endosome
GO:0005771 multivesicular body
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031982 vesicle
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0044194 cytolytic granule
GO:0061474 phagolysosome membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002000 Lysosome-associated membrane glycoprotein
PFAM PF01299
PRINTS PR00336
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q05204
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281897
UniGene Bt.5330
RefSeq NP_001068592
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118436 BC133619 BC140610 L09113
GenPept AAA30548 AAI18437 AAI33620 AAI40611

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca