Version 5.4
Bos taurus Protein: ALOX12
Summary
InnateDB Protein IDBP-686243.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALOX12
Protein Name arachidonate 12-lipoxygenase, 12S-type
Synonyms 15-LOX; ALOX12;
Species Bos taurus
Ensembl Protein ENSBTAP00000015911
InnateDB Gene IDBG-634446 (ALOX12)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004052 arachidonate 12-lipoxygenase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0008289 lipid binding
GO:0016491 oxidoreductase activity
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872 metal ion binding
GO:0047977 hepoxilin-epoxide hydrolase activity
GO:0050473 arachidonate 15-lipoxygenase activity
GO:0051213 dioxygenase activity
Biological Process
GO:0001503 ossification
GO:0002820 negative regulation of adaptive immune response
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006646 phosphatidylethanolamine biosynthetic process
GO:0008284 positive regulation of cell proliferation
GO:0010811 positive regulation of cell-substrate adhesion
GO:0019369 arachidonic acid metabolic process
GO:0019372 lipoxygenase pathway
GO:0030282 bone mineralization
GO:0030838 positive regulation of actin filament polymerization
GO:0034976 response to endoplasmic reticulum stress
GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway
GO:0035963 cellular response to interleukin-13
GO:0042060 wound healing
GO:0043066 negative regulation of apoptotic process
GO:0043277 apoptotic cell clearance
GO:0055114 oxidation-reduction process
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071277 cellular response to calcium ion
GO:1901074 regulation of engulfment of apoptotic cell
GO:2001303 lipoxin A4 biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005811 lipid particle
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001024 PLAT/LH2 domain
IPR001885 Lipoxygenase, mammalian
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR013819 Lipoxygenase, C-terminal
PFAM PF01477
PF00305
PRINTS PR00467
PR00087
PIRSF
SMART SM00308
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P27479
PhosphoSite PhosphoSite-
TrEMBL Q6SYC4
UniProt Splice Variant
Entrez Gene 282139
UniGene
RefSeq NP_776926
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY445523 DAAA02048758 M62516 M81320 S96247
GenPept AAA30346 AAB21522 AAC41614 AAR15705

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca